Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals

Bioenergetic constraints for conversion of syngas to biofuels in acetogenic bacteria

Synthesis gas (syngas) is a gas mixture consisting mainly of H2, CO, and CO2 and can be derived from different sources, including renewable materials like lignocellulose. The fermentation of syngas to certain biofuels, using acetogenic bacteria, has attracted more and more interest over the last years. However, this technology is limited by two things: (1) the lack of complete knowledge of the ...

Ethical Debates on Synthetic Biology

Background: As an emerging interdisciplinary area of science with a multitude of potential facilities and applications, synthetic biology integrates different disciplines with one another ranging from basic science to engineering. This interdisciplinary branch therefore encompasses sciences that require specific development and ethical approaches. Materials and Methods: Science management princ...

Energy conservation in acetogenic bacteria.

Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria.

Covalent modification of proteins with ubiquitin (Ub) is widely implicated in the control of protein function and fate. Over 100 deubiquitylating enzymes rapidly reverse this modification, posing challenges to the biochemical and biophysical characterization of ubiquitylated proteins. We circumvented this limitation with a synthetic biology approach of reconstructing the entire eukaryotic Ub ca...

Synthetic Biology Approaches to Combat Antibiotic Resistant Bacteria

Synthetic biology (SB) is an innovative and emerging field, representing a confluence of science and engineering. It aims to (re)-design biological parts, devices and systems while applying engineering principles for useful applications. Valuable insight gained on the functions of biological systems will further improve the design capacity. The advance of SB is expected to provide solutions to ...